三七三醇皂苷类成分药物代谢特性的研究进展
作者:黄永亮;杨华蓉;王莉;马茹君;徐志毅;吴纯洁;
Author:
收稿日期: 年卷(期)页码:2014,29(04):-460-463
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:三七三醇皂苷;药物代谢动力学;药物渗透性;生物转化
Key words:
基金项目:国家发展改革委员会现代中药高新技术产业发展专项:三七通舒胶囊等生产过程质量控制先进技术综合示范应用研究[发改办高校(2011)51号文];;
四川省科技成果转化项目(专项):三七通舒胶囊欧盟药品注册国际合作研究成果转化(编号:2011CHZ0002);;
“重大新药创制”科技专项“十二五”计划“创新药物孵化基地”分课题:三七通舒国际化(欧盟)药品注册研究[编号:2011ZX09401-304(5-3)]
中文摘要
三七三醇皂苷是中药三七的重要有效成分,在治疗缺血性心脑血管疾病方面起着重要作用。文中系统综述了近年来国内外学者对三七三醇皂苷主要成分的吸收、分布、代谢、排泄等特性的研究概况。
参考文献
[1]李昊,孙建国,谢海棠,等.大鼠肠管外翻模型对人参皂苷Rg1吸收机制的研究[J].中国临床药理学与治疗学,2004,9(5):510-513.
[2]李文兰,南莉莉,季宇彬,等.人参中人参皂苷Rg1、Rb1大鼠在体肠吸收机制的研究[C].中药饮片质量分析与中药鉴别技术交流研讨会论文集,2009:156-161.
[3]邓震亭,孟林.大鼠不翻转小肠囊模型对三七皂苷R1吸收的研究[J].中国实验方剂学杂志,2011,17(11):142-144.
[4]萨础拉,吕航,姜艳艳,等.三七皂苷在大鼠外翻肠囊中的吸收及与P-糖蛋白相互作用研究[J].北京中医药大学学报,2011,34(12):836-842.
[5]冯亮,蒋学华,周静,等.三七皂苷R1和人参皂苷Rg1的大鼠在体肠吸收动力学研究[J].中国药学杂志,2006,41(14):1097-1102.
[6]Liu HF,Yang JL,Du FF,et al.Absorption and disposition of Ginsenosides after oral administration of Panax notoginseng extract to rats[J].Drug Metab Dispos,2009,37(12):2290-2298.
[7]王玉珠,薛燕,陈雾,等.人参皂苷Rg1及其代谢产物脑内分布的研究[C].第八次全国药物与化学异物代谢学术会议论文摘要,2006:39.
[8]WANG R,LI YN,WANG GJ,et al.Neuroprotective effects and brain transport of ginsenoside Rg1[J].Chinese J Natural Med,2009,7(4):315-320.
[9]WANG R,WANG GJ,WU XL,et al.Ginsenoside Rg1attenuates structural disruption of the blood-brain barrier to protect the central nervous system in ischemia/reperfusion[J].Chin J Nat Med Jan,2013,11(1):30-37.
[10]何百寅,谢友良,刘常青,等.三七提取液中三七皂苷R1、人参皂苷Rg1和人参皂苷Rb1的透皮规律研究[J].中国实验方剂学杂志,2011,17(21):130-134.
[11]白志华,方晓玲.三七总皂苷中人参皂苷Rg1体外透皮吸收的实验研究[J].中成药,2006,28(5):639-641.
[12]汪新芳,汪冰,王平,等.三七皂苷R1体外透皮吸收累计渗透量的研究[J].时珍国医国药,2010,21(10):2579-2580.
[13]陈新梅,朱家壁,孙卫东,等.冰片对人参皂苷Rg1鼻腔吸收的促进作用及鼻腔纤毛毒性研究[J].中国药学杂志,2006,41(4):261-264.
[14]陈新梅,朱家壁,孙卫东,等.吸收促进剂对人参皂苷Rg1鼻腔吸收的促进作用及鼻腔毒性[J],药学学报,2006,41(2):149-155.
[15]Odani T,Tanizawa H,Takino Y.Studies on the absorption,distribution,excretion and metabolism of ginseng saponinsⅡ.The absorption,distribution and excretion of ginsenoside Rg1in the rat[J].Chem Pharm Bull,1983,31:292-298.
[16]Strmbom J,Sandberg F,Dencker L.Studies on absorption and distribution of ginsenoside Rg1by whole-body autoradiobiography and chromatography[J].Acta Pharm Suec,1985,22:113-122.
[17]Karikura M,Miyase T,Tanizawa H,et al.Studies on absorption,distribution,excretion and metabolism of ginseng saponins V.The decomposition products of ginsenoside Rb2in the large intestine of rats[J].Chem Pharm Bull,1990,38:2859-2861.
[18]Hasegawa H,Sung JH,Benno Y.Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins[J].Planta Med,1996,63:436-440.
[19]Akao T,Kanaoka M,Kobashi K.Appearance of compound K,a major metabolite of ginsenoside Rb1by intestinal bacteria,in rat plasma after oral administration-measurement of compound K by enzyme immunoassay[J].Biol Pharm Bull,1998,21:245-249.
[20]Han BH,Park MH,Han YN,et al.Degradation of ginseng saponins under mild acidic conditions[J].Planta Med,1982,44:146-149.
[21]Hasegawa H,Sung JH,Matsumiya S,et al.Main ginseng metabolites formed by intestinal bacteria[J].Planta Med,1996,62:453-455.
[22]韩旻,韩丽妹,王青松,等.三七皂苷的口服吸收机制[J].药学学报,2006,41(6):498-505.
[23]韦凤华,宋林,何毅,等.人参皂苷Rg1在大鼠体内的代谢与排泄研究[J].华西药学杂志,2010,25(3):302-305.
[24]冯亮,胡昌江,余凌英.人参皂苷Rg1及其代谢产物的药代动力学研究[J].药学学报,2010,45(5):636-640.
[25]刘昌孝.我国药代动力学研究发展的回顾[J].中国药学杂志,2010,45(2):81-89.
[26]Chen W,Dang YJ,Zhu CY.Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study[J].Chinese Medicine,2010,5:12-17.
[27]韩旻,傅韶,方晓玲.三七皂苷中人参皂苷Rg1与Rb1口服吸收及其体内药代动力学的研究和比较[J].药学学报,2007,42(8):849-853.
[28]冷静,林大胜,杨华蓉,等.三七三醇皂苷两种制剂在比格犬体内的药物动力学研究[J].华西药学杂志,2011,26(2):158-161.
[29]何希辉,炎彬,潘卫松,等.三七皂苷中R1、Rg1在正常和脑缺血再灌大鼠中的动力学变化[J].中药药理与临床,2001,17(6):12-14.
[30]Yosioka I,Sugawara T,Imai K.Soil bacterial hydrolysis:Leading to genuine aglycone V on ginsenosides-Rb1,Rb2,and Rc of the gsinseng root saponins[J].Chem Pharm Bull,1972,11:2418-2421.
[31]陈新梅.大鼠肠道酶和菌群对人参皂苷Rg1的代谢转化研究[J].中国实验方剂学杂志,2011,17(11):210-212.
[32]Wang YZ,Wang YS,Chu SF,et al.Protopanaxatriol metabolites identified by LC-MS/MS after oral administration in mice[J].Int J Clin Pharmacol Ther,2010,48(4):282-290.
[33]Ruan JQ,Leong WI,Yan R,et al.Characterization of metabolism and in vitro permeability study of notoginsenoside R1from Radix notoginseng[J].J Agric Food Chem,2010,58(9):5770-5776.
[34]Eun-Ah BAE,Ji-eun SHIN,Dong-Hyun KIM.Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect[J].Biol Pharm Bull,2005,28(10):1903-1908.
[35]陈广通,高慧媛,宋妍,等.人参皂苷Rg1在大鼠体内的代谢研究[J].中国现代中药,2008,10(11):37-40.
[36]陈广通,杨敏,果德安.人参皂苷Re在大鼠体内的代谢研究[J].中国中药杂志,2009,34(12):1540-1543.
[37]陈广通,杨敏.三七皂苷R1在大鼠体内的代谢产物分析[J].时珍国医国药,2010,21(2):485-487.
【关闭】