HPLC同时测定盐酸曲唑酮中的7种有关物质
Simultaneous determination of seven related substances of Trazodone hydrochloride by HPLC
作者：邹国芳;闫鹏;孙玉静;耿颖姝;薛昊;李巍;
Author：
收稿日期： 年卷（期）页码：2014,29(04):-452-454
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：高效液相色谱法;盐酸曲唑酮;有关物质
Key words：
基金项目：
中文摘要
目的采用HPLC法同时测定盐酸曲唑酮中的7种有关物质。方法采用TopsilTMC18色谱柱(250 mm×4.6 mm,5μm),流动相为二乙胺-乙腈-水(0.4∶57∶43),检测波长254 nm,流速1.5 mL·min-1。结果各有关物质的色谱峰与盐酸曲唑酮的主峰完全分离,盐酸曲唑酮的线性范围为0.5～10.0μg·mL-1,方法的重复性的RSD=7.50%。结论所用方法灵敏、简单、重复性好,可用于盐酸曲唑酮相关物质的检测。
参考文献
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