OGP-49羟丙基-β-环糊精包合物的研究
Study on the inclusion complex of OGP-49 with hydroxypropyl-β-cyclodextrin
作者:郑滑;胡海英;张正全;李雪冰;张健平;
Author:
收稿日期: 年卷(期)页码:2012,27(03):-247-249
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:OGP-49;羟丙基-β-环糊精;包合物;溶解度
Key words:
基金项目:国家重大新药创制专项(2009ZX09102-154)
中文摘要
目的制备OGP-49羟丙基-β-环糊精包合物,为OGP-49的注射给药提供基础。方法采用超声法制备。经差示扫描量热法、红外光谱法验证包合物的形成。结果羟丙基-β-环糊精和OGP-49以20∶1的比例形成包合物,40%的羟丙基-β-环糊精可使OGP-49的水中溶解度提高330倍。结论 OGP-49羟丙基-β-环糊精包合物能显著提高OGP-49的水中溶解度。
参考文献
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