星点设计-效应面法优化水飞蓟宾双层片的处方
Preparation and study on the in vitro release of silybin double-layer tablets
作者:阮佳;岑菁;袁志翔;徐超群;
Author:
收稿日期: 年卷(期)页码:2013,28(04):-378-381
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:水飞蓟宾;双层片;星点设计;效应面法
Key words:
基金项目:
中文摘要
目的制备难溶性药物水飞蓟宾的双层片,考察其处方因素和体外释药行为,优化水飞蓟宾双层片的处方。方法经单因素考察,确定影响体外释药行为的主要因素,利用星点设计-效应面法优化处方,并对优化处方进行验证。结果缓释层中HPMC K4M、乳糖对水飞蓟宾双层片的体外释药行为有显著影响,依据最优处方制备的缓释片在0.5~12 h内呈良好的缓释释药特征,12 h累积释药率达到80%以上。结论采用星点设计-效应面法得到了水飞蓟宾双层片处方的优化模型,实现了该双层片的处方优化。
参考文献
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