缬沙坦对自发性高血压大鼠肾脏和脑组织中血管紧张素转化酶2表达的影响
Effect of Valsartan on the expression of angiotensin converting enzyme 2 in kidney and brain of spontaneously hypertensive rats
作者：孙经武;刘冉冉;刘成霞;房灿;
Author：
收稿日期： 年卷（期）页码：2013,28(04):-356-359
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：缬沙坦;自发性高血压大鼠;肾脏;脑组织;血管紧张素转换酶2;血管紧张素Ⅱ受体拮抗剂
Key words：
基金项目：山东省医药科技发展计划(No.2009HW008)
中文摘要
目的研究缬沙坦对自发性高血压大鼠肾脏和脑组织中血管紧张素转化酶2(ACE2)表达的影响,探讨ACE2对肾脏及脑组织中的保护作用。方法选取24只(♂)12周龄的自发性高血压大鼠(SHR),随机均分为缬沙坦组和SHR组;选取12只正常♂Wistar大鼠做为对照组。缬沙坦组大鼠ig给予缬沙坦30 mg.kg-1.d-1,而SHR组及对照组均给予等量0.9%氯化钠溶液。10周后处死大鼠,取出肾脏及脑组织,HE染色法观察各组大鼠肾脏及脑组织的病理变化,免疫组织化学法和逆转录聚合酶链反应(RT-PCR)法测各组大鼠肾脏及脑组织中ACE2的表达差异。结果与正常大鼠相比,缬沙坦组、SHR组大鼠肾脏及脑组织中ACE2的表达明显减低(P
参考文献
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