姜黄素诱导HO-1的表达与抗动脉粥样硬化大鼠的脂质过氧化的研究
Study on the effect of heme oxygenase-1 expression induced by crucumin on anti-lipid peroxidation in the atherosclerotic rats
作者：刘全未;黄维义;
Author：
收稿日期： 年卷（期）页码：2012,27(04):-399-401
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：姜黄素;血红素氧化酶-1;动脉粥样硬化;脂质过氧化
Key words：
基金项目：四川省自然科学基金资助项目(04JY029-021-3)
中文摘要
目的观察姜黄素诱导HO-1高表达及其对动脉粥样硬化(AS)大鼠血清中氧化低密度脂蛋白(ox-LDL)、丙二醛(MDA)含量的影响。方法将34只健康♂Wistar大鼠,随机分为正常对照组(n=8)、模型组(n=10)、姜黄素组(n=8)及抑制组(n=8),模型组、姜黄素组及抑制组同法复制AS模型,姜黄素组加用姜黄素,抑制组加用姜黄素及锌原卟啉Ⅸ;第14周末处死所有大鼠,取降主动脉检测HO-1的表达、分布及活力,经心脏取血检测ox-LDL、MDA的含量。结果姜黄素组较模型组的HO-1表达量及活力明显增强(P
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