氟尿嘧啶隐形泡囊的制备及其体外性质的研究
Study on the preparation and properties of Fluorouracil stealth niosomes in vitro
作者：黄娟;刘艳丽;杨红;尹宗宁;吴秀凤;万智慧;冒华健;刘洪月;
Author：
收稿日期： 年卷（期）页码：2012,27(04):-388-390
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：氟尿嘧啶;隐形泡囊;理化性质;体外细胞试验
Key words：
基金项目：国家自然科学基金资助项目(批准号:30572262)
中文摘要
目的制备氟尿嘧啶隐形泡囊并考察其理化性质和体外细胞毒性。方法用自制Plu-Chol,以改良注入法制备氟尿嘧啶隐形泡囊,考察泡囊的形态、粒径、电位、包封率和体外释放特性,通过MTT比色法比较泡囊与原药对Hela细胞的作用效应。结果氟尿嘧啶隐形泡囊在电镜下的外观为球形,平均粒径为904.87±0.45 nm,Zeta电位为-66.75 mV,包封率为30.93%±1.71%;体外释放符合Weibull distribution模型,且具有明显的缓释性(氟尿嘧啶隐形泡囊释药t1/2为游离氟尿嘧啶的3.75倍);细胞毒性试验表明泡囊对Hela细胞的杀伤作用明显优于原药(IC50降低了83.95%,P
参考文献
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