抗肿瘤天然产物ainsliatrimer A前体化合物的合成
Synthesis of the precursor compound of anti-tumor natural product ainsliatrimer A
作者：陈怡;宋颢;
Author：
收稿日期： 年卷（期）页码：2012,27(04):-356-359
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：合成中间体;愈创木内酯;抗肿瘤活性;Ainsliatrimer A
Key words：
基金项目：
中文摘要
目的合成ainsliatrimer A重要的前体化合物。方法以5-(叔丁基二甲硅氧基)戊-1-醇为原料,通过亲核取代、Wittig反应、羰基加成等关键反应,制备抗肿瘤天然产物ainsliatrimer A的前体化合物。结果与讨论通过7步反应合成了ainsliatrimer A全合成中的重要前体化合物,总收率为27.1%,可为ainsliatrimer A和ainsliatrimer B的全合成研究奠定基础。
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