5种抗肿瘤中药注射液对CYP3A4酶代谢的影响
Influence of 5 anti-tumor traditional Chinese medicine injections on CYP3A4 of liver microsomes
作者：杨旭平;赖丹;黄毅岚;钟小燕;
Author：
收稿日期： 年卷（期）页码：2014,29(05):-550-552
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：抗肿瘤中药注射液;肝微粒体;细胞色素P4503A4;药-药相互作用
Key words：
基金项目：泸州医学院附属医院项目
中文摘要
目的以睾酮为探针药物,于体外研究5种抗肿瘤中药注射液(康艾、消癌平、华蟾素、参附、注射用香菇多糖)对大鼠细胞色素P4503A4(CYP3A4)亚型酶活性的影响。方法采用大鼠肝微粒体体外孵育法,用HPLC法测定5种抗肿瘤中药注射液孵育体系中6β-羟基睾酮的生成量,反映其对CYP3A4酶活性的影响。结果与空白组相比,参附对CYP3A4酶活性无明显影响;华蟾素对CYP3A4有诱导作用;康艾、香菇多糖、消癌平对CYP3A4有抑制作用,消癌平的IC50为0.69%。结论在临床上经CYP3A4代谢的药物联合应用时,应警惕华蟾素、康艾、香菇多糖、消癌平潜在的药-药相互作用。
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