肾细胞体外模型在药物评价与筛选中的应用
作者:王磊;张金晓;张宗鹏;申秀萍;
Author:
收稿日期: 年卷(期)页码:2012,27(05):-597-599
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:肾细胞体外模型;肾毒性;药物评价与筛选
Key words:
基金项目:“重大新药创制”科技重大专项“十二五”计划-毒性生物标记物与人源化动物模型关键技术(2012ZX09505001-001)
中文摘要
对肾细胞体外模型及其在药物评价与筛选中的应用作一综述,并提出几点新的研究思路。
参考文献
[1]Prieto P.Barriers,nephrotoxicology and chronic testing in vitro[J].Altern Lab Anim,2002,30(2):101-106.
[2]Peyrou M,Cribb AE.Effect of endoplasmic reticulum stress pre-conditioning on cytotoxicity of clinically relevant nephrotoxins inrenal cell lines[J].Toxicol in Vitro,2007,21(5):878-886.
[3]Tribolo S,Maroux S,Massey-Harroche D.Kidney proximal tu-bule cells:Epithelial cells without EGTA-extractable annexins[J].Biochem Cell Biol,2000,78(4):495-502.
[4]Levashova ZB,Plisov SY,Perantoni AO.Conditionally immortal-ized cell line of inducible metanephric mesenchyme[J].KidneyInt,2003,63(6):2075-2087.
[5]Mihwa K,Minjae K,Sang WP,et al.Isoflurane protects humankidney proximal tubule cells against necrosis via sphingosinekinase and sphingosine-1-phosphate generation[J].Am JNephrol,2010,31(4):353-362.
[6]Patrina G,Katarina A,Kazuhiro K,et al.Comparison of the novelHK-2 human renal proximal tubular cell line with the standardLLC-PK1 cell line in studying drug-induced nephrotoxicity[J].Cancer J Physiol Pharm,2010,88(4):448-455.
[7]Li W,Choy DF,Lam MS,et al.Use of cultured cells of kidneyorigin to assess specific cytotoxic effects of nephrotoxins[J].Tox-icology in vitro,2003,17(1):107-113.
[8]闫长会,吴纯启,廖明阳.肾近端小管细胞系在药物肾毒性评价中的应用[J].国外医学药学分册,2003,30(4)∶234-237.
[9]Yuan J,Zhou J,Chen BC,et al.Magnesium supplementation pre-vents chronic cyclosporine nephrotoxicity via adjusting nitric oxidesynthase activity[J].Transplant Proc,2005,37(4):1892-1895.
[10]Gennari A,Cortese E,Boveri M,et al.Sensitive endpoints forevaluating cadmium-induced acute toxicity in LLC-PK1 cells[J].Toxicology,2003,183(1-3):211-220.
[11]Bouslimi A,Ouannes Z,Golli EE,et al.Cytotoxicity and oxidativedamage in kidney cells exposed to the mycotoxins ochratoxin Aand citrinin:Individual and combined effects[J].Toxicol MechMethod,2008,18(4):341-349.
[12]Dai GD,Cui LB,Song L,et al.Induction of bladder lesion byterephthalic acid and its mechanism[J].Biomed Environ Sci,2005,18(4):211-219.
[13]韦敏,刘华钢,刘丽敏.白花丹素的体外肾毒性研究[J].中成药,2009,31(11):1753-1755.
[14]肖亿.氟尿嘧啶的体外肾毒性研究[J].山西医药杂志,2009,38(5):452-453.
[15]戴伟,顾光,高芃,等.原代肝、肾细胞培养在保健食品原料毒性筛选中的应用[J].中国食品卫生杂志,2010,22(3):233-236.
[16]王志鹏,梅其炳,刘琳娜,等.庆大霉素对人肾小管上皮细胞系(HK-2)热休克蛋白(HSP)70表达的影响[J].中国药理学通报,2006,22(4):497-500.
[17]唐爱存,张志伟,黄仁彬,等.原代肾细胞体外培养及其在药物毒理学中的应用[J].中外健康文摘,2009,6(8):211-214.
[18]Ip MM,Darcy KM.Three-dimensional mammary primary culturemodel systems[J].J Mammary Gland Biol Neoplasia,1996,1(1):91-110.
[19]Sikka PK,McMartin KE.Normal rat kidney proximal tubule cellsin primary and multiple subcultures[J].In Vitro Cell Dev BiolAnim,1996,32(5):285-291.
[20]Xu JJ,Henstock PV,Dunn MC,et al.Cellular imaging predictionsof clinical drug-induced liver injury[J].Toxicol Sci,2008,105(1):97-105.
[21]Hoffmann D,Fuchs TC,Henzler T,et al.Evaluation of a urinarykidney biomarker panel in rat models of acute and subchronicnephrotoxicity[J].Toxicology,2010,277(1-3):49-58.
【关闭】