10-取代1-氮杂苯并蒽酮衍生物的抗肿瘤和抗菌活性研究
Antitumor and antimicrobial activity of 10-substituted 1-azabenzanthrone derivatives
作者：唐煌;赵海涛;姚静婧;覃江克;
Author：
收稿日期： 年卷（期）页码：2014,29(05):-522-524
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：1-氮杂苯并蒽酮;DNA结合;抗肿瘤;抑菌
Key words：
基金项目：国家自然科学基金资助项目(批准号:81260471,21002015);;
广西自然科学基金(2013GXNSFAA019038)
中文摘要
目的研究10-取代1-氮杂苯并蒽酮衍生物与小牛胸腺DNA的相互作用及其抗肿瘤和抗菌活性。方法利用紫外吸收光谱法研究衍生物与小牛胸腺DNA的相互作用;运用MTT法检测化合物对肺癌细胞(NCI-H460)、人肝癌细胞(HepG2)和肝癌细胞7404的毒性;运用滤纸片扩散法测试化合物对金黄色葡萄球菌、巨大芽孢杆菌、伤寒沙门氏菌和枯草芽孢杆菌的抑菌能力。结果化合物能与小牛胸腺DNA发生嵌入结合作用;大多数的化合物对上述3种肿瘤细胞有较强的毒性,其IC50
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