阿托伐他汀对80例急性脑梗死患者血清中妊娠相关蛋白A和基质金属蛋白酶的影响
作者：胡仁琳;华梅;李鸣;凌芳;聂德云;
Author：
收稿日期： 年卷（期）页码：2013,28(06):-647-649
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：脑梗死;阿托伐他汀;妊娠相关蛋白A;基质金属蛋白酶-8;动脉粥样硬化
Key words：
基金项目：武汉市卫生局科研资助项目(编号:WX10C23)
中文摘要
目的探讨阿托伐他汀对急性脑梗死患者血清中妊娠相关蛋白A(PAPP-A)及基质金属蛋白酶-8(MMP-8)水平的影响,观察其对颈动脉易损斑块的消退作用及评估卒中再发风险。方法将160例经颈动脉超声检查的急性脑梗死患者均分为颈动脉稳定斑块组(对照组)和颈动脉易损斑块组(治疗组),易损斑块组抽血检查后均分为阿托伐他汀低、高剂量组(10、40mg·d-1)。比较治疗前及治疗后4周各组血清中PAPP-A和MMP-8的水平;观察治疗前及治疗后12个月颈动脉的内-中膜厚度(IMT值)、斑块Crouse积分及斑块回声的变化。结果治疗前,阿托伐他汀低、高剂量血清中PAPP-A和MMP-8的水平均高于对照组,但两组间血清中PAPP-A和MMP-8的水平差异无显著性。治疗后4周,阿托伐他汀高剂量组血清中PAPP-A和MMP-8的水平均显著低于低剂量组(P
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