盐酸胺碘酮-羟丙基-β-环糊精包合物的制备与表征
Preparation and characterization of inclusion complex of amiodarone hydrochloride with hydroxypropyl-β-cyclodextrin
作者：景姜辉;任丽莉;陈国广;
Author：
收稿日期： 年卷（期）页码：2014,29(05):-500-502
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：盐酸胺碘酮;羟丙基-β-环糊精;包合技术
Key words：
基金项目：
中文摘要
目的制备并鉴定盐酸胺碘酮羟丙基-β-环糊精包合物(Ami-HP-β-CD)。方法运用溶液搅拌法制备AmiHP-β-CD包合物,考察溶剂极性对包合物溶解度的影响及介质的稳定性,利用UV、DSC、FT-IR、1HNMR等方法鉴定包合物的结构。结果低极性溶剂的加入使包合物的溶解度增加,包合前后物质的波谱图存在显著差异。结论 HP-β-CD能显著提高Ami的溶解度及溶出速率,低极性溶剂有利于包合物的溶解。波谱方法显示新的物象特征,表明了包合物的形成。
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