疏水性肺表面活性蛋白SP-B结构类似物的研究进展
作者：王鹏;王万能;吕婧;蔡晓娜;张良;邱俊;周继红;刘大维;
Author：
收稿日期： 年卷（期）页码：2013,28(06):-636-639
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：肺表面活性蛋白B;类似物;α螺旋;疏水性;研究进展
Key words：
基金项目：军队十二五重大项目资助(AWS11J5008)
中文摘要
肺表面活性蛋白B(SP-B)类似物α作为肺表面活性物质治疗剂,基于天然SP-B蛋白N-端、C-端、连接区域序列为模板的类似物在体外、体内试验中都表现出了良好的活性,其中类似物SP-B1-25与KL4表现最为突出,KL4已成功上市。同时基于SP-B蛋白N-端与C-端连结序列的Mini-B结构和根据其特殊的α螺旋结构设计的合成肽也显示出了很好的生物活性,显示出了成为SP-B替代物的巨大潜力。这些研究成果为人工合成表面活性物质替代天然表面活性物质治疗剂的应用作出了重要贡献。文中综述了SP-B结构类似物的研究进展。
参考文献
[1]Possmayer F.A proposed nomenclature for pulmonary surfactantassociated proteins[J].Am Rev Respir Dis,1988,138(8):990-998.
[2]Svetlana B,Peter T.Direct simulation of protein-mediated vesicle fusion:Lung surfactant protein B[J].Biophysical,2010,99(8):2134-2142.
[3]Olmeda B,García-álvarez B,Pérez-Gil J.Structure-function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins[J].Eur Biophys,2013,42(2-3):209-222.
[4]Zaltash S,Palmblad M,Curstedt T,et al.Pulmonary surfactant protein B:A structural model and a functional analogue[J].Biochim Biophys Acta,2000,1466(7):179-186.
[5]Frey SL,Pocivavsek L,Waring AJ,et al.Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B[J].Am J Physiol Lung Cell Mol Physiol,2010,298(3):L335-347.
[6]Veldhuizen EJ,Waring AJ,Walther FJ,et al.Dimeric N-terminal segment of human surfactant protein B(dSP-B1-25)has enhanced surface properties compared to monomeric SP-B1-25[J].Biophys J,2000,79(1):377-384.
[7]Serrano AG,Ryan M,Weaver TE,et al.Criticalstructure-function determinants within the N-terminal Region of pulmonary surfactant protein SP-B[J].Biophys J,2006,90(1):238-249.
[8]Revak SD,Merritt TA,Hallman M,et al.The use of synthetic peptides in the formation of biophysically and biologically-active pulmonary surfactants[J].Pediatric Research,1991,29(4):460-465.
[9]Antharam VC,Farver RS,Kuznetsova A,et al.Interactions of the C-terminus of pulmonary surfactant B with lipid bilayers are modulated by acyl chain saturation[J].Biochim Biophys Acta,2008,1778(11):2544-2554.
[10]Cochrane CG,Revak SD.Pulmonary surfactant protein B(SPB):structure-function relationships[J].Science,1991,25(5):254-566.
[11]Saleem M,Meyer MC,Breitenstein D,et al.The surfactant peptide KL4 in lipid monolayers:Phase behavior,topography,and chemical distribution[J].Biol Chem,2008 283(8):5195-5207.
[12]Antharam VC,Elliott DW,Mills FD,et al.Penetration depth of surfactant peptide KL4into membranes is determined by fatty acid saturation[J].Biophys,2009,96(10):4085-4098.
[13]Long JR,Mills FD,Ganesh OK,et al.Partitioning dynamics and orientation of lung surfactant peptide KL4in phospholipid bilayers[J].Biochim Biophys Acta,2010,1798(2):216-222.
[14]Revak SD,Merritt TA,Cochrane CG,et al.Efficacy of synthetic peptide-containing surfactant in the treatment of respiratory distress syndrome in preterm infant rhesus monkeys[J].Pediatr Res,1996,39(1):715-724.
[15]Zimmermann AM,Roberts KD,Lampland AL,et al.Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury[J].Pediatr Pulmonol,2010,45(8):782-788.
[16]Moen MD,Perry CM,Wellington K.Lucinactant:in neonatal respiratory distress syndrome[J].Treat Respir Med,2005,4(2):139-145.
[17]Nilsson G,Gustafsson M,Vandenbussche G,et al.Synthetic peptide-containing surfactants evaluation of transmembrane versus amphipathic helices and surfactant protein C poly-valyl to poly-leucyl substitution[J].Biochem,1998,255(3):116-124.
[18]Zaltash S,Palmblad M,Curstedt T,et al.Pulmonary surfactant protein B:A structural model and a functional analogue[J].Biochim Biophys Acta,2000,1466(5):179-186.
[19]Palleboina D,Waring AJ,Notter RH,et al.Effects of the lung surfactant protein B construct Mini-B on lipid bilayer order and topography[J].Eur Biophys,2012,41(9):755-67.
[20]Walther FJ,Waring AJ,Hernandez-Juviel JM,et al.Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs[J].PLoS ONE,2010,5(1):1-20.
[21]McLean LR,Lewis JE,Krstenansky JL,et al.An amphipathicα-helical decapeptide in phosphatidylcholine is an effective synthetic lung surfactant[J].Am Rev Respir Dis,1993,147(4):462-465.
[22]Patch JA,Barron AE.Mimicry of bioactive peptides via non-natural,sequence-specificpeptidomimetic oligomers[J].Chem Biol,2002,6(1):872-877.
[23]Seurynck SL,Patch JA,Barron AE.Simple,helical peptoid analogs of lung surfactant protein B[J].Chem Biol,2005,12(1):77-88.
[24]Dohm MT,Seurynck-Servoss SL,Seo J,et al.Close mimicry of lung surfactant protein B by“clicked”dimers of helical cationic peptoids[J].Biopolymers,2009,92(6):538-553.
【关闭】
