尼莫地平纳米粉制备过程中的晶型转化及影响因素
Investigation on the polymorphic transformation and the influence factors in the preparation of Nimodipine nanocrystals
作者：王玥;李益;吴送姑;龚俊波;王永莉;魏振平;
Author：
收稿日期： 年卷（期）页码：2014,29(05):-491-493
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：尼莫地平;纳米粉;晶型转化;反溶剂沉淀法;高压均质
Key words：
基金项目：国家自然基金资助项目(批准号:201176173);;
天津市自然科学基金(编号:14JCYBJC29100)
中文摘要
目的考察尼莫地平纳米粉制备过程中的晶型转化和引起晶型转化的因素。方法利用反溶剂沉淀重结晶法联合高压均质技术得到尼莫地平纳米粉悬浮液,再经冷冻干燥得到其纳米粉;用X-射线粉末衍射法和差示扫描量热法鉴定尼莫地平的晶型;用激光粒度仪及扫描电子显微镜考察其粒径及形态。结果尼莫地平在反溶剂沉淀过程中的晶型由Ⅰ型转化成了Ⅱ型,在高压均质过程中未出现晶型转化。结论制备尼莫地平纳米粉过程中,易产生溶剂介导的晶型转化,而高压均质过程中的机械作用对晶型转化影响较小。
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