合欢皮有效部位对bFGF诱导小鼠血管生成的影响及其机制
The effects of Albizia julibrissin active fraction on angiogenesis induced by bFGF in rat model and its related mechanism
作者：马丽萍;邱丽颖;冯磊;韩金臻;杜斌;
Author：
收稿日期： 年卷（期）页码：2013,28(06):-583-586
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：合欢皮有效部位;bFGF;血管生成;pAKT;pERK
Key words：
基金项目：
中文摘要
目的研究合欢皮有效部位(AJAF)对bFGF诱导血管生成的影响,并探讨其抑制血管生成的机制。方法采用bFGF诱导小鼠Matrigel种植体血管生成的模型,Masson染色和CD31免疫荧光法评价AJAF对微血管面积变化的影响;免疫组织化学法测定靶蛋白pAKT,pERK的表达量。结果 AJAF能够显著降低Matrigel种植体微血管面积,并呈现剂量依赖性,且pAKT、pERK的表达量随药物浓度的升高而显著降低。结论 AJAF抑制bFGF诱导的Matrigel种植体内血管生成,此作用与下调pAKT,pERK的表达量有关。
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