联合用药在抗肿瘤纳米递药系统中的应用
作者：许秀丽;黄园;
Author：
收稿日期： 年卷（期）页码：2014,29(06):-720-722
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：抗肿瘤;联合用药;纳米递药系统;脂质体;聚合物-药物接合物;胶束
Key words：
基金项目：国家自然科学基金资助项目(批准号:81072600)
中文摘要
多药联合应用已成为临床上治疗肿瘤的首选方案。纳米药物传递系统可改善抗肿瘤药物的体内分布及药动学性质,提高药物对特定靶点的选择性,达到高效低毒的治疗目的。文中简要综述纳米递药系统在抗肿瘤联合用药方面的研究进展、面临的挑战及发展趋势。
参考文献
[1]Logman JFS,Heeg BMS,Botteman MF,et al.Economic evaluation of zoledronic acid for the prevention of osteoporotic fractures in postmenopausal women with early-stage breast cancer receiving aromatase inhibitors in the UK[J].Annals Oncology,2010,21(7):1529-1536.
[2]Liu XY,Mc TANT,Lee HS.In vitro cytotoxicity of Stealth liposomes co-encapsulating doxorubicin and verapamil on doxorubicin-resistant tumor cells[J].Biol Pharm Bull,2005,28(5):822-828.
[3]Shaikh IM,Tan KB,Chaudhury A,et al.Liposome co-encapsulation of synergistic combination of irinotecan and doxorubicin for the treatment of intraperitoneally grown ovarian tumor xenograft[J].J Control Rel,2013,172(3):852-861.
[4]Zucker D,Barenholz Y.Optimization of vincristine–topotecan combination—Paving the way for improved chemotherapy regimens by nanoliposomes[J].J Control Rel,2010,146(3):326-333.
[5]Zhang Y,Wang J,Bian D,et al.Targeted delivery of RGD-modified liposomes encapsulating both combretastatin A-4 and doxorubicin for tumor therapy:In vitro and in vivo studies[J].Eur J Pharmaceut Biopharmaceut,2010,74(3):467-473.
[6]Bilim V.Technology evaluation:PK1,Pfizer/Cancer Research UK[J].Cur Opinion Molecul Therap,2003,5(3):326-330.
[7]Sapra P,Mehlig M,Malaby J,et al.EZN-2208,a novel polyethyleneglycol-SN38 conjugate,has potent antitumor activity in a panel of human tumor xenografts[C].American association of cancer research annual meeting poster,2007:1494.
[8]Vicent MJ,Greco F,Nicholson RI,et al.Polymer therapeutics designed for a combination therapy of hormone-dependent cancer[J].Angewandte Chemie,2005,117(26):4129-4134.
[9]Greco F,Vicent MJ,Gee S,et al.Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells[J].J Control Rel,2007,117(1):28-39.
[10]Lammers T,Subr V,Ulbrich K,et al.Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers[J].Biomater,2009,30(20):3466-3475.
[11]Etrych T,írováM,Starovoytova L,et al.HPMA copolymer conjugates of paclitaxel and docetaxel with p H-controlled drug release[J].Molecul Pharmaceut,2010,7(4):1015-1026.
[12]Xiao H,Li W,Qi R,et al.Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy[J].J Control Rel,2012,163(3):304-314.
[13]Wang Y,Ma S,Xie Z,et al.A synergistic combination therapy with paclitaxel and doxorubicin loaded micellar nanoparticles[J].Colloids Surfaces B:Biointerfaces,2014,116:41-48.
[14]Desale SS,Cohen SM,Zhao Y,et al.Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer[J].J Control Rel,2013,171(3):339-348.
[15]Sun TM,Du JZ,Yao YD,et al.Simultaneous delivery of siRNA and paclitaxel via a“two-in-one”micelleplex promotes synergistic tumor suppression[J].Acs Nano,2011,5(2):1483-1494.
[16]Zheng C,Zheng M,Gong P,et al.Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy[J].Biomaterials,2013,34(13):3431-3438.
[17]Zhao J,Mi Y,Feng SS.Targeted co-delivery of docetaxel and si Plk1 by herceptin-conjugated vitamin E TPGS based immunomicelles[J].Biomaterials,2013,34(13):3411-3421.
[18]Ganta S,Amiji M.Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells[J].Molecular Pharmaceut,2009,6(3):928-939.
[19]D’Arrigo G,Navarro G,Di MC,et al.Gellan gum nanohydrogel containing anti-inflammatory and anti-cancer drugs:A multidrug delivery system for a combination therapy in cancer treatment[J].Eur J Pharmaceut Biopharmaceut,2013.
[20]Liu Y,Lu WL,Guo J,et al.A potential target associated with both cancer and cancer stem cells:A combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes[J].J Control Rel,2008,129(1):18-25.
[21]Ke XY,Lin NVW,Gao SJ,et al.Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells[J].Biomaterials,2014,35(3):1096-1108.
[22]Verschraegen CF,Skubitz K,Daud A,et al.A phase I and pharmacokinetic study of paclitaxel poliglumex and cisplatin in patients with advanced solid tumors[J].Canc Chemother Pharmacol,2009,63(5):903-910.
[23]Nemunaitis J,Cunningham C,Senzer N,et al.Phase I study of CT-2103,a polymer-conjugated paclitaxel,and carboplatin in patients with advanced solid tumors[J].Canc Investig,2005,23(8):671-676.
【关闭】
