氨氯地平联用松龄血脉康胶囊对大鼠的血药浓度及降压作用的影响
Effects of combination of Amlodipine and Songling Xuemai Kang capsule on the drug concentration in plasma and antihypertensive effect in spontaneously hypertensive rat
作者：吴建明;高小平;柯潇;郝晓锋;张志荣;
Author：
收稿日期： 年卷（期）页码：2012,27(06):-646-649
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：氨氯地平片;松龄血脉康胶囊;联合用药;血药浓度;高血压
Key words：
基金项目：
中文摘要
目的探讨氨氯地平片联用松龄血脉康胶囊对大鼠血药浓度的影响以及协同降压作用。方法选取15只自发性高血压大鼠(SHR),随机分为氨氯地平片(20 mg.kg-l)组、同时给药组(20 mg.kg-l氨氯地平片+0.9 g.kg-l松龄血脉康胶囊)组、延时给药组(20 mg.kg-l氨氯地平片+0.9 g.kg-l松龄血脉康胶囊,延时30 min);ig给药并于氨氯地平片给药后不同时间点采集血样,HPLC法测定各时间点氨氯地平的血药浓度,采用DAS 2.0软件计算药物动力学参数。另选取SHR大鼠比较同时给药及延时给药的协同降压作用。结果同时给药组增加了大鼠血浆中的氨氯地平浓度和曲线下面积(P
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