麦角碱的生产及生物合成的研究进展
作者：王雅琴;刘红娟;李海;黄辰;陆群;
Author：
收稿日期： 年卷（期）页码：2015,30(01):-109-112
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：麦角碱;生物合成;酶学;生产;吲哚衍生物;棒麦角素;D-麦角酸;麦角肽;研究进展;综述
Key words：
基金项目：
中文摘要
麦角碱为具多种结构和生物活性的吲哚类衍生物。文中综述了麦角碱的生产、共有生物合成途径及分支途径的最新研究进展。
参考文献
[1]Wallwey C,Li SM.Ergot alkaloids:Structure diversity,biosynthetic gene clusters and functional proof of biosynthetic genes[J].Nat Prod Rep,2011,28(3):496-510.
[2]Schardl CL,Panaccione DG,Tudzynski P.Ergot alkaloids–biology and molecular biology[J].Alkaloids:Chem Biology,2006,63:45-86.
[3]Arora DK.Fungal biotechnology in agricultural,food,and environmental applications[M].New York:Marcel Dekker,2004:150-165.
[4]Pazoutova S,Tudzynski P.Claviceps sp.PRL 1980(ATCC26245),59 and Pepty 695/ch-I:their true story[J].Mycol Res,1999,103(8):1044-1048.
[5]Kren V.Ergot:The genus Claviceps[M].Netherlands:Harwood Academic Publischers,1999:321-371.
[6]Robinson T,Singh D,Nigam P.Solid-state fermentation:A promising microbial technology for secondary metabolite production[J].Appl Microbiol Biotech,2001,55(3):284-289.
[7]胡晨曦,杨金玲,程克棣,等.麦角碱生物合成途径中酶学及相关基因研究进展[J].西北植物学报,2005,25(4):819-828.
[8]HulvováH.Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids[J].Biotechnology Advances,2013,31(1):79-89.
[9]Lorenz N,Haarmann T,Pazoutova S,et al.The ergot alkaloid gene cluster:Functional analyses and evolutionary aspects[J].Phytochemistry,2009,70(15):1822-1832.
[10]Panaccione DG,Ryan KL,Schardl CL,et al.Analysis and modification of ergot alkaloid profiles in fungi[J].Methods Enzymology,2012,515:267.
[11]Goetz KE,Coyle CM,Cheng JZ,et al.Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus[J].Current Genetics,2011,57(3):201-211.
[12]Matuschek M,Wallwey C,Wollinsky B,et al.In vitro conversion of chanoclavine-I aldehyde to the stereoisomers festuclavine and pyroclavine controlled by the second reduction step[J].RSC Advances,2012,2(9):3662-3669.
[13]Haarmann T,Ortel I,Tudzynski P,et al.Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways[J].Chem Bio Chem,2006,7(4):645-652.
[14]卢春霞,王洪新.麦角生物碱的研究进展[J].食品科学,2010(011):282-288.
[15]Lorenz N,Wilson EV,Machado C,et al.Comparison of ergot alkaloid biosynthesis gene clusters in Claviceps species indicates loss of late pathway steps in evolution of C.fusiformis[J].Appl Environ Microbiol,2007,73(22):7185-7191.
[16]Mai P,Li SM.Alkaloids derived from tryptophan:A focus on ergot alkaloids[J].Springer-Verlag Berlin Heidelberg,Natural Products,2013,683-714.
[17]Oeser B,Beaussart F,Haarmann T,et al.Expressed sequence tags from the flower pathogen Claviceps purpurea[J].Mol Plant Pathol,2009,10(5):665-684.
【关闭】
