芹黄素联合紫杉醇对人乳腺癌MCF-7细胞株增殖、迁移及凋亡的影响
Effects of apigenin combined with Paclitaxel on the proliferation,migration and apoptosis of human breast cancer cell line MCF-7
作者：王阳;齐庆涛;
Author：
收稿日期： 年卷（期）页码：2015,30(01):-51-53
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：芹黄素;紫杉醇;联用;增殖;迁移;凋亡;人乳腺癌;MCF-7细胞株
Key words：
基金项目：
中文摘要
目的探讨芹黄素联合紫杉醇对人乳腺癌MCF-7细胞株增殖、迁移及凋亡的影响。方法采用MTT法测定人乳腺癌MCF-7细胞的增殖活性;用Transwell法测试细胞的迁移情况;用流式细胞仪检测细胞的凋亡。结果芹黄素与紫杉醇单独用药对细胞的抑制作用随药物浓度的提高而增强,呈浓度依赖性,联合用药有协同作用;两药联用后,抑制细胞的迁移能力和诱导细胞的凋亡作用增强。结论芹黄素与紫杉醇联用可协同抑制人乳腺癌MCF-7细胞的增殖和迁移,并诱导细胞的凋亡。
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