薯蓣皂苷元抗肿瘤衍生物的设计与合成(Ⅲ)
The design and synthesis of diosgenin anti-tumor derivatives(Ⅲ)
作者：郑微;蒋红平;吴亚克;范举正;
Author：
收稿日期： 年卷（期）页码：2011,26(02):-107-111
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：薯蓣皂苷元衍生物;合成;抗肿瘤活性
Key words：
基金项目：
中文摘要
目的设计、合成薯蓣皂苷元衍生物并研究其体外抗肿瘤活性。方法以Autodock 4.0为辅助工具设计化合物,采用酰化和取代的方法制备;用MTT法对人恶性黑色素瘤细胞A375、人肺腺癌细胞A549、人肝癌细胞HepG-2进行体外抗肿瘤活性的试验。结果所制9个新化合物的结构经1HNMR,13CNMR确证。药理结果表明:大部分化合物具有一定的抗肿瘤活性。结论化合物Ⅴ、Ⅶ、Ⅹ有较好的抗肿瘤活性。
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