肾靶向脂质体配体巯基葡萄糖-胆甾偶联物的设计与合成
Synthesis of sulfhydryl glucose-cholesterol as ligand for kidney targeting liposomes
作者：肖湘;樊维;蒋庆琳;吴勇;海俐;
Author：
收稿日期： 年卷（期）页码：2011,26(03):-221-223
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：肾靶向;脂质体配体;胆固醇;巯基葡萄糖;合成
Key words：
基金项目：
中文摘要
目的设计并合成一种新型的肾靶向脂质体配体巯基葡萄糖-胆固醇偶联物。方法胆固醇与对甲苯磺酰氯成酯后与癸二醇取代,甲磺酰氯磺酰化制得6-(5-胆甾烯-3-氧基)-1-甲烷磺酰氧基癸烷,再与1,2,3,4-四-O-乙酰基-1-巯基-吡喃葡萄糖成醚后由甲醇钠脱保护后得到目标配体。结果成功合成一个胆甾巯基葡萄糖偶联物。结论目标化合物已经IR、1HNMR、MS确证。
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