聚乙二醇化艾塞那肽对肥胖恒河猴的减肥作用
Anti-obesity effect of Pegylated exenatide in obese rhesus monkeys
作者：潘虹;杨遵远;汤春贵;徐敏;曾文;龚立;
Author：
收稿日期： 年卷（期）页码：2015,30(02):-175-178
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：聚乙二醇化艾塞那肽;减肥;恒河猴;药效学;摄食量;奥利司他
Key words：
基金项目：国家科技支撑计划项目(2012BAI23B08;2014BAI03B01)
中文摘要
目的研究聚乙二醇化艾塞那肽(PB199)长期给药对肥胖恒河猴的减肥作用。方法一个月内每周一次sc PB199,观察其对肥胖恒河猴体重、腹部脂肪体积、摄食量、血糖和血脂等肥胖相关指标的影响。结果给药一个月后,模型对照组动物的体重与给药前比增加1.34%,3、6μg·kg-1PB199组猴的体重与给药前比分别降低5.14%、5.68%,较模型对照组的差异显著(P
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