用M-NRTL模型及平衡空气法交叉验证甘氨酸溶液的渗透压
Cross-validating the osmotic pressure based on modified NRTL model with air humidity osmometry over the whole concentration of glycine solutions
作者：谭晓莹;詹婷婷;詹先成;王晓兰;徐敖;付茜;李成容;
Author：
收稿日期： 年卷（期）页码：2015,30(02):-165-166
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：渗透压;活度系数;M-NRTL模型;平衡空气法;甘氨酸
Key words：
基金项目：国家自然科学基金资助项目(批准号:81273444)
中文摘要
目的尝试通过药物溶液的浓度计算其渗透压。方法采用M-NRTL模型,由甘氨酸溶液浓度计算其渗透压,并应用平衡空气法测定溶液的渗透压。结果应用双向单侧t检验法和多重检验调整法进行验证,结果显示M-NRTL模型的计算值与平衡空气法的测定值具有等效性。结论可以应用物理模型由药物溶液的浓度计算渗透压值。
参考文献
[1]Christina J,Arnd J,Friedrich EK,et al.Tear film osmolarity measurements in dry eye disease using electrical impedance technology[J].Cornea,2011,30(12):1289-1292.
[2]Grattoni A,Canavese G,Montevecchi FM,et al.Fast membrane osmometer as alternative to freezing point and vapor pressure osmometry[J].Anal Chem,2008,80(7):2617-2622.
[3]Zhan XC,Li H,Yu L,et al.Determining osmotic pressure of drug solutions by air humidity in equilibrium method[J].Drug Development and Industrial Pharmacy,2013:1-4.
[4]Pazuki GR,Taghikhani V,Vossoughi M.Correlation and prediction the activity coefficients and solubility of amino acids and simple peptide in aqueous solution using the modified local composition model[J].Fluid Phase Equilibria J,2007,255:160-166.
[5]Pazukia GR,Nikookarb M.A new local composition model for predicting of activity coefficient and solubility of amino acids and peptides in water[J].Biochemical Engineering,2006,28:44-49.
[6]Kirkwood TBL,Westlake WJ.Bioequivalence testing-a need to rethink[J].Biometric,1981,37(3):589-594.
[7]Benjamini Y,Hochberg Y.Controlling the false discovery rate:A practical and powerful approach to multiple testing[J].J Royal Statistical Society.Series B(Methodological),1995,57(1):289-300.
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