星点设计-效应面法优化溴新斯的明多囊脂质体的制备工艺
Preparation of Neostigmine bromide multivesicular liposomes using the central composite design-response surface methodology
作者：万坤;孙立力;罗文;熊华蓉;张景勍;
Author：
收稿日期： 年卷（期）页码：2015,30(02):-148-151
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：溴新斯的明;多囊脂质体;包封率;工艺优化;星点设计-效应面法
Key words：
基金项目：
中文摘要
目的采用星点设计-效应面法优化溴新斯的明多囊脂质体的制备工艺。方法采用复乳法制备溴新斯的明多囊脂质体,以包封率为评价指标,用星点设计优化处方,并进行多元线性回归与二项式方程拟合,采用效应面法选取较佳工艺条件,并进行预测。结果以磷脂与胆固醇为1.41∶1投料、主药浓度为22.98 g·L-1、三油酸甘油酯为24.93 mmol·L-1的优化条件制备溴新斯的明多囊脂质体,包封率为80.34%±1.53%,与二项式拟合方程预测结果相差小于2.5%。结论应用星点设计-效应面法优化溴新斯的明多囊脂质体的制备工艺,能快速方便地得到最佳制备工艺,预测性良好。
参考文献
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