丹参酮ⅡA自纳米乳的制备及其质量的评价
Preparation and quality evaluation of tanshinone ⅡA self nano emulsifying drug delivery system
作者：闫碧涵;于小月;刘美;程勐;王银艳;储婷;毛声俊;
Author：
收稿日期： 年卷（期）页码：2015,30(02):-143-145
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：丹参酮ⅡA;自乳化;溶出速率;质量评价;伪三元相图法;高效液相色谱法
Key words：
基金项目：
中文摘要
目的研制丹参酮ⅡA自纳米乳来增加药物的溶出率。方法采用伪三元相图法,以乳剂外观、粒径、Zeta电位为指标优选处方,采用HPLC测定丹参酮ⅡA,考察其药剂学特性。结果优选处方为Tween80-PEG400-MCT(31∶62∶7),载药量1.5 mg·m L-1,平均粒径42.63±1.80 nm,多分散系数PDI为0.16±0.037,Zeta电位为-12.35±0.96 m V。以0.5%Tween80为溶出介质,丹参酮ⅡA自纳米乳在1.5 h时的累积释药量即可达载药量的55%。结论丹参酮ⅡA自纳米乳可显著提高药物的溶出速率。
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