没食子酸在大鼠体内对1,2-二氯-4-硝基苯代谢的影响
Effects of gallic acid on DCNB metabolic in vivo
作者：张有金;陈加容;杨志勇;
Author：
收稿日期： 年卷（期）页码：2015,30(03):-344-346
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：谷胱甘肽硫转移酶;没食子酸;体内;1,4-二氯-2-硝基苯;解毒机制;代谢;最低检测限;大鼠
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基金项目：
中文摘要
目的考察没食子酸在大鼠体内对1,2-二氯-4-硝基苯(DCNB)代谢的影响。方法将大鼠随机分为空白组(生理盐水)和没食子酸组(20 mg·kg-1),连续给药14 d,再给予DCNB,不同时间点于眼眶静脉取血,用GC法检测血浆中DCNB的浓度,绘制药时曲线,用DAS3.2.1计算药动学参数。结果 DCNB的线性范围为0.025~10.0μmol·L-1,最低检测限为25nmol·L-1,日内、日间RSD均
参考文献
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