拉帕替尼白蛋白纳米粒冻干粉针的制备与表征
Preparation and characterization of freeze-dried Lapatinib incorporated albumin-lipid nanoparticles
作者：袁端锋;何勤;高会乐;
Author：
收稿日期： 年卷（期）页码：2015,30(03):-279-281
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：拉帕替尼;白蛋白纳米粒;冻干粉针;制备;工艺;冻干支架;透射电镜
Key words：
基金项目：国家重大科学研究计划973项目(2013CB932504)
中文摘要
目的制备和表征拉帕替尼白蛋白纳米粒,并优化冻干粉针的工艺。方法将拉帕替尼与白蛋白在体外结合后,用卵磷脂分散即得拉帕替尼白蛋白纳米粒;采用粒径仪和冷冻透射电镜进行表征;采用单因素和正交设计对冻干粉针的工艺和支架剂进行优化。结果该纳米粒只需通过简单的搅拌、旋转蒸发即可得到,工艺简便;粒径为66.8 nm,Zeta电位约20 m V,经电镜表征证明该纳米粒为明显的核壳结构;6%牛血清白蛋白作为冻干支架剂的效果最好,冻干复溶后粒径约110 nm。结论成功制备了拉帕替尼冻干粉针,其具较好的复溶效果。
参考文献
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