星点设计-效应面法优化丹参酮ⅡA冻干乳的处方
Optimization of the formulation of tanshinone ⅡA freezing-drized submicron emulsion by Central composite design-response surface method
作者：刘美;程勐;闫碧涵;毛声俊;
Author：
收稿日期： 年卷（期）页码：2015,30(05):-558-560
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：丹参酮IIA;冻干乳;星点设计-效应面法;处方优化;冻干保护剂;制备
Key words：
基金项目：
中文摘要
目的优化丹参酮ⅡA冻干乳的处方。方法采用高压乳匀法制备丹参酮ⅡA冻干乳,以粒径和综合评分为指标,以麦芽糖和β-环糊精的用量及冻干乳剂体积为考察因素,采用星点设计-效应面法优化处方。结果优选的处方为:以20%麦芽糖、0.2%β-环糊精为冻干保护剂,冻干体积为0.4 m L;所制丹参酮ⅡA冻干乳的外观结实、平整,加水再分散性好,粒径为375 nm。结论所建数学模型预测性良好,适合丹参酮ⅡA冻干乳的处方优化。
参考文献
[1]李慧,石华月,储婷,等.丹参酮ⅡA与丹参酮ⅡA磺酸钠对K562细胞的增殖抑制与诱导分化作用[J].华西药学杂志,2011,26(3):226-229.
[2]Yu XY,Lin SG,Zhou ZW,et al.Role of P-glycoprotein in the intestinal absorption of tanshinone IIA,a major active ingredient in the root of Salvia miltiorrhiza[J].Curr Drug Metab,2007,8(4):91-107.
[3]赵栋,龚涛,梁湖沂,等.星点设计-效应面优化法优化注射用Cheliensisin冻干乳剂[J].华西药学杂志,2007,22(3):275-279.
[4]张青,马伟从,张霞,等.星点设计-效应面优化法优化低密度脂蛋白纳米粒处方与制备工艺[J].华西药学杂志,2013,28(1):12-15.
[5]Chu T,Zhang Q,Li H,et al.Development of intravenous lipid emulsion of tanshinone IIA and evaluation of its anti-hepatoma activity in vitro[J].Int J Pharm,2012,424:76-88.
【关闭】
