甲氧苄啶中相关杂质的合成
Synthesis of the related impurities of Trimethoprim
作者：杨冬华;米洁;成丽;吴勇;
Author：
收稿日期： 年卷（期）页码：2015,30(05):-537-539
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：甲氧苄啶;杂质;合成;缩合;重排;加成;环合
Key words：
基金项目：
中文摘要
目的设计合成甲氧苄啶(TMP)的2个重要杂质TMP-A和TMP-F。方法以3,4,5-三甲氧基苯甲醛为原料,经过缩合、重排、加成、环合、氯代及亲核取代制得TMP-A。以香兰素为原料,经过缩合、重排、加成和环合制得TMP-F。结果与结论成功制备了TMP-A,收率较文献提高。首次合成TMP-F,所设计路线的反应条件温和,试剂廉价易得,操作简单。
参考文献
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