和厚朴酚在肿瘤治疗中的研究进展
作者:闵玲;朱小牧;胡丽娜;
Author:
收稿日期: 年卷(期)页码:2010,25(01):-113-115
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:和厚朴酚;厚朴酚;肿瘤;治疗
Key words:
基金项目:
中文摘要
和厚朴酚可诱导肿瘤细胞凋亡,促进肿瘤细胞分化,抑制新生血管生长、肿瘤转移、细胞增殖等作用,其抗肿瘤效应具有多靶点、多效应、不良反应低的特点。综述和厚朴酚在肿瘤治疗中的作用机制及研究进展。
参考文献
[1]Kim BH,Cho JY.Anti-inflammatory effect of honokiol ismedi-ated by P BK/Akt pathway suppression[J].Acta Pharmacol Sin,2008,29(1):113-122.
[2]Xu Q,Yi LT,Pan ZY,et al.Antidepressant like effects of the mixture of honokiol and magnolol from the barks of Magnolia offic in alis in stressed rodents[J].Prog Neuropsychopharmacol Biol Psychiatry,2008,32(3):715-725.
[3]Fei C,Tao W,Yi F W,et al.Honokiol:A potent chemotherapy candidate for human colorectal carcinoma[J].World J Gastroen-terol,2004,10(23):3459-3463.
[4]Tao W,Fei C,Zhe C,et al.Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO[J].World J Gastroenterol,2004,10(15):2205-2208.
[5]Shu-Er Y,Ming-Tsuen H,Tung-Hu T,et al.Down-modulation of Bcl-XL,release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in hu-man squamous lung cancer CH27cells[J].Biochem Pharm,2002,63(9):1641-1651.
[6]Eun-R yeong H,Shivendra VS.Honokiol causes G0-G1phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1transcriptional activity[J].Mol Cancer Ther,2007,6(10):2686-2695.
[7]Fong WF,Tse AK,Poon KH,et al.Magnolol and honokiol en-hance HL-60human leukemia cell differentiation induced by1,25-di-hydroxyvitam in D3and retinoic acid[J].Int J Bio-chem Cell Biol,2005,37(2):427-441.
[8]Kenji I,Teru H,Makoto H,et al.Honokiol overcomes convention-al drug resistance in human multiple myeloma by inductionof caspase-dependent and independent apoptosis[M].Blood First Edition Paper,2005,106(5):1794-1800.
[9]Lee SY,Yuk DY,Song HS,et al.Growth inhibitory effects of obo-vatol through induction of apoptotic cell death in prostate and co-lon cancer by blocking of NF-kappaB[J].EurJ Pharmacol,2008,582(1):17-25.
[10]Li L,HAN W,QIU S,et al.Honokiol induces a necrotic cell death through mitochondrial permeability transition pore[J].Cancer Research,2007,67(10):4894-4903.
[11]Nagase H,Ikeda K,Sakai Y.Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080.Invasiveness in vitro[J].Planta Med,2001,67(8):705-708.
[12]Xianhe B,Francesca C,Masuko UF,et al.Honokiol,a small mo-lecular weight natural product,inhibits angiogenesis in vitro and tumor growth in vivo[J].J Biol Chem,2003,278(37):35501-35507.
[13]Certo M,MooreV,Nishino M,et al.Mitochondria primed by death signals detemine cellular addiction to antiapoptotic BCL-2fami-ly members[J].Cancer Cell,2006,9(5):351-365.
[14]Battle TE,Arbiser J,Frank DA.The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lym-phocytic leukemia(B-CLL)cells[J].Blood,2005,106(2):690-7.Epub2005Mar31.
[15]Xu D,Lu Q,Hu X.Down-regulation of P-glycoprotein ex-pression in MDR breast cancer cell MCF-7/ADR by honokiol[J].Cancer Lett,2006,243(2):274-280.
[16]Xu W,Kwang C,Zhuo C,et al.Honokiol reduces drug resistance by inhibition of P-glycoprotein expression in multidrug resistant(MDR)squamous cell carcinoma of the head and neck(SC-CHN)[J].AACR Meeting Abstracts,2007,2776(98):14-18.
[17]Liu Y,Zhao X,Wei Y,et al.Enhancement of therapeutic effec-tiveness by combining liposomal honokiol with cisplatin in ovarian carcer[J].Int J Gynecol Cancer,2008,18(4):652-659.
【关闭】