胰岛素磷脂复合物自微乳传递系统的制备
Formulation of self-nanoemulsifying drug delivery systems for insulin-soybean lecithin complex
作者：何娜;张莉;朱峰;蒯锐;袁明清;何勤;
Author：
收稿日期： 年卷（期）页码：2010,25(04):-396-399
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：胰岛素;亲脂性;自微乳传递系统
Key words：
基金项目：四川省科技支撑计划项目(2009SZ0141)
中文摘要
目的构建胰岛素磷脂复合物自微乳传递系统(ISC-SNEDDS)。方法利用冻干法制备胰岛素磷脂复合物(ISC),根据其溶解性选择油相,确定复合物中胰岛素(INS)与磷脂(SPC)的最佳质量比;利用假三相图法,通过乳化后的外观和粒径筛选最优空白自微乳处方并制备载药自微乳制剂。结果制成磷脂复合物后,胰岛素在油酸乙酯中的溶解度显著增加;自微乳的最优处方为ethyl oleate-cremophor EL-alcohol(35:32.5:32.5),以0.01mol·L-1 HCl稀释10倍后,平均粒径为30.79±1.57nm,多分散系数PDI为0.132±0.025。结论胰岛素磷脂复合物可以增加胰岛素在油酸乙酯中的溶解度,其自微乳制剂的制备方法简单,稀释后粒径均一。
参考文献
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