绿原酸对Lewis肺癌小鼠及人A549肺癌的实验研究
Study on antitumor effects of chlorogenic acid on Lewis and A549 lung carcinoma
作者：孙秋艳;刘艳;汪茜;刘洁;包旭;
Author：
收稿日期： 年卷（期）页码：2010,25(05):-536-538
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：绿原酸;A549肺癌;Lewis肺癌;协同作用;移植瘤
Key words：
基金项目：四川省科学技术厅应用基础研究顶目(编号:2009JY0029)
中文摘要
目的研究绿原酸对肺癌的影响及联合用药后对化疗药物的增敏作用。方法采用MTT法研究绿原酸对人肺癌A549细胞增殖的影响,绿原酸对移植瘤的影响及对化疗药物的增敏作用。结果绿原酸对人肺癌A549细胞增殖无影响,对Docetaxel(1.6μg·mL-1)无增敏作用;对A549肺癌有一定抑制趋势,可明显抑制Lewis肺癌的生长;联合用药在一定程度上可提高抗肿瘤作用,但对化疗药物的抗肿瘤作用无协同性。结论绿原酸对人肺癌A549细胞无细胞毒作用;对A549肺癌无明显抑制作用,但可明显抑制Lewis肺癌的生长,联合阿霉素用药对抗肿瘤无增敏作用。
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