盐酸米诺环素脂质体的制备工艺研究
Preparation of Minocycline hydrochloride liposome
作者：龚巧燕;李沉纹;康丽;龚道琼;刘锡勇;尹宗宁;
Author：
收稿日期： 年卷（期）页码：2010,25(05):-521-523
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：盐酸米诺环素;脂质体;制备;高效液相色谱法
Key words：
基金项目：
中文摘要
目的考察盐酸米诺环素脂质体的制备工艺,测定脂质体的含量,并评价其质量。方法用薄膜分散法制备盐酸米诺环素脂质体,以包封率为指标,单因素优化制备工艺;以RP-HPLC测定盐酸米诺环素的含量。结果盐酸米诺环素脂质体最佳工艺为:药脂比1∶30,PC-CH(8∶1),水化时间150min,PBS体积10mL,PBS的pH6.5。平均包封率为76.5%±0.8%;平均粒径为103.2nm,PDI为0.211,Zeta电位为-16.5mV。结论优化后的制备工艺可靠,可用于制备盐酸米诺环素脂质体。
参考文献
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