藁本内酯对脑缺血再灌注大鼠的作用及其抗炎机制的研究
Study on the effect of Z-ligustilide on rats with tMCAO and the mechanism of its anti-inflamatory
作者：王雁南;杜俊蓉;
Author：
收稿日期： 年卷（期）页码：2010,25(06):-685-687
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：脑缺血再灌注;藁本内酯;炎症因子;脑血流;神经保护
Key words：
基金项目：
中文摘要
目的观察藁本内酯对再灌注局灶性脑缺血损伤大鼠模型的神经保护作用及其炎症因子的调控。方法采用局部脑血流监测,建立线栓法大鼠脑缺血再灌注(tMCAO)模型。SD大鼠随机分为假手术组、溶媒对照组和药物治疗组。除假手术组外,于再灌注后0、3 h分别ip给予3%吐温80溶媒、20 mg.kg-1藁本内酯。缺血2 h后再灌注,24 h后进行神经功能评分,经TTC染色法测定脑组织梗死体积,并在实验过程中监测脑局部血流的下降和再灌注情况。给药后24 h,对大鼠脑组织进行免疫组织化学实验分析统计,从蛋白水平上观察藁本内酯对炎症因子NF-κB的控制作用。结果藁本内酯能显著改善tMCAO大鼠神经功能(P
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