丹参酮ⅡA抑制血管紧张素Ⅱ诱导的大鼠心肌细胞肥大
TanshinoneⅡA prevents angiotensinⅡ-induced hypertrophy of cardiomyocytes from rat
作者：龚丽娅,郑智,熊玮,孙联平
Author：
收稿日期： 年卷（期）页码：2004,(01):-24-27
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：血管紧张素Ⅱ;丹参酮ⅡA;心肌细胞肥大;原癌基因c-fos
Key words：
基金项目：湖北省科技攻关课题 ( 2 0 0 2AA3 0 1C2 9)
中文摘要
目的 在原代培养的新生大鼠心肌细胞上 ,观察丹参酮ⅡA(TSN)对血管紧张素Ⅱ (AngⅡ )诱导的心肌细胞肥大的影响。方法 采用3 H -亮氨酸掺入法测定心肌细胞蛋白质合成速率 ,作为心肌细胞肥大的指标 ;用逆转录聚合酶链式反应检测心肌细胞原癌基因c -fosmRNA的表达。结果 TSN能抑制AngⅡ诱导的大鼠心肌细胞蛋白质合成的增加 (P
参考文献
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