3,4-亚甲二氧基苯丙胺对空间学习记忆功能的急性影响
Spatial learning and memory function of the acute effects of MDMA
作者：李素霞,彭祖贵,黄明生,李静,况伟宏,王雪,李进
Author：
收稿日期： 年卷（期）页码：2004,(02):-125-127
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：3,4-亚甲二氧基甲基苯丙胺;学习与记忆;Morris水迷宫
Key words：
基金项目：
中文摘要
目的 探讨3,4-亚甲二氧基苯丙胺(MDMA)对大鼠空间学习记忆功能的急性影响。方法 对照组(A)腹腔注射等体积生理盐水,实验组(B、C、D、E)分别腹腔注射MDMA 3、5、10、20 mg·kg-1;两组分别于用药后第7天行Morris水迷宫实验。结果 无论是定向航行实验、还是空间探索实验,对照组与实验组(MDMA 3、50、10、20 mg·kg-1)大鼠在逃避潜伏期和穿原平台所在位置的次数上均无统计学差异。结论 MDMA对成年大鼠的学习记忆功能无明显影响。
参考文献
[1] Liesbeth Reneman MD, Jules Lavalaye MD, Ben Schmand phD, et al. Cartical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine( MDMA or "Ecstasy")[J]. Arch Gen Psychiatry,2001,58:901
[2] Sarajane Bhattachary, Jane H Powell. Recreational use of 3, 4-methylenedioxymethamphetamine(MDMA)or "ecstasy": evidence for cognitive impairment[J] .Psychological Medicine,2001,31:647
[3] Schmidt CJ, Neurotoxicity of the psychedelic amphetamine, methylene-dioxymethamphetamine.[J].Pharmachol Exp Ther, 1987,247:1
[4] McKenna DJ, Peroutka SJ. Neurochemistry and neurotoxicity of 3,4-methylenedioxymethamphetamine ( MDMA," Ecstasy ") [J]. Neu-rochem,1990,54:14
[5] O' Heam E, Battaglia G, DeSouza EB, et al. Methylene dioxyam-phetamine ( MDA ) and methylenedioxymethamphetamine ( MDMA ) cause selective ablation of serotonergic axon terminals in the fore-brain : immunocytochemical evidence for neurotoxicity [J]. Neurosci, 1988,8:2788
[6] Ricaurte GA, Fomo LS, Wilson MA, et al. (±) Methylene dioxymethampheta-mine selectively damages central serotonergic neurons in nonhuman primates[J] .JAMA, 1988,260:51
[7] Broening HW, MorfordLL, Inman-WoodSL, et al. 3,4-methylene-dioxymetham-phetamine (ecstasy)-induced learning and memory impairments depend on the age of exposure during early development [J].J Neuroscience,2001,21(9) :3228
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