控缓释制剂载体材料聚己内酯的制备及表征
Preparation and characterization of a novel modified-released drug carrier(poly-ε-caprolactone)
作者：蒋青锋,陈建海,陈志良,阎玺庆,杨莉
Author：
收稿日期： 年卷（期）页码：2004,(04):-260-263
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：聚己内酯;载体材料;控缓释制剂
Key words：
基金项目：广东省科技计划项目 (编号 :2 0 0 2C3 0 10 3 )
中文摘要
目的 制备新型控缓释制剂载体材料聚己内酯 ,并探讨其结构和性质。方法 以纯化后单体为底物、钛酸丁酯为引发剂 ,通过控制单体与引发剂的投料比 ,催化开环聚合得适宜分子量的产物。结果 聚合反应有良好的收率 ,聚合产物有良好的分子量分布宽度。凝胶渗透色谱法 (GPC)、傅立叶变换红外光谱 (FT -IR)、热重分析 (TGA)、X -射线衍射 (XRD)表征为所需物质。结论 所用工艺可获得理想分子量的产物 ,工艺简单并具有良好的重复性。
参考文献
[1] BerrabahM ,ZahidiA .PreparationofPoly-ε-caprolactonenanocap sulesbynanoprecipitationandtheirevaluationusingbenzylbenzoateandGC -MS[J].JPharmClin,1999,18(4):3132
[2] LiSM ,VertM .Biodegradationofaliphaticpolyesters.InGScott,D .Fileadeds,Degradablepolymers:Principlesandapplications[M ].London:Chapman&Hall,1995.43
[3] SabelleYdens,DelphineRutot,PhilippeDeg啨e,etal.Controlledsyn thesisofpoly(ε-caprolactone)-grafteddextrancopolymersaspoten tialenvironmentallyfriendlysurfactants[J].Macromolecules,2000,33:6713
[4] SongY ,LiuL ,WengX ,etal.Acid-initiatedpolymerizationofep silon-caprolactoneundermicrowaveirradiationanditsapplicationinthepreparationofdrugcontrolledreleasesystem[J].JBiomaterSciPolymEd,2003,14(3):241
[5] PittCG .Polycaprolactoneanditscopolymers.InLargerR ,andChasinMEds.Biodegradablepolymerasdrugdeliverysystems[M].NewYork:MarcelDekker,1990.70
[6] SoYeonKim,YoungMooLee.Taxol-loadedblockcopolymernanospherescomposedofmethoxypoly(ethyleneglycol)andpoly(ε-caprolactone)asnovelanticancerdrugcarriers[J].Biomaterials,2001,22:1697
[7] ChristineAllen,JeannieHan,YuYisong,etal.Polycaprolactone-b-poly(ethyleneoxide)copolymermicellesadadeliveryvehiclefordihy drotestosterone[J].JournalofControlledRelease,2000,63:275
[8] JinWooLee,Fengjun-hua,DooSungLee.Thermoreversiblegela tionofbiodegradablePoly(ε-caprolactone)andpoly(ethylenegly col)mutiblockcopolymersinaqueoussolutions[J].JournalofControlledRelease,2001,73:315
[9] ChongSuCho,SooYeonHan,Jeong-HunHa,etal.Clonazepamre leasefrombioerodiblehydrogelsbasedonsemi-interpenetratingpolymernetworkscomposedofpoly(ε-caprolactone)andpoly(ethy leneglycol)macromer[J].IntJpharmaceutics,1999,181:235
【关闭】
