雷贝拉唑、阿莫西林和硫糖铝根除幽门螺杆菌的疗效观察
Triple therapy with Rabeprazole,Amoxicillin and Sucralfate for eradication of Helicobacter pylori in duodenal ulcer disease
作者：高建;李孝生;吴显才;沈薇;何璐;
Author：
收稿日期： 年卷（期）页码：2006,(02):-213-214
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：幽门螺杆菌;三联疗法;雷贝拉唑;阿莫西林;硫糖铝
Key words：
基金项目：
中文摘要
目的观察雷贝拉唑、阿莫西林和硫糖铝三联疗法对根除幽门螺杆菌(HP)的疗效。方法将95例经胃镜检查确诊为十二指肠溃疡活动期,并经快速尿素酶试验和14C-尿素呼气试验,确定为HP阳性的患者分为两组。A组以雷贝拉唑0.01 g(qd),阿莫西林1 g(bid)和硫糖铝1 g(qid)治疗2周;B组以雷贝拉唑0.01 g(qd),阿莫西林1 g(bid)和克拉霉素0.5 g(bid)治疗2周。于用药结束后,第28天复查胃镜,观察溃疡愈合情况并检查HP。结果A组的HP根除率为91.5%,B组为93.8%,两组无显著性差异(P>0.05);A组溃疡的愈合率(93.6%)稍高于B组(89.6%),但无显著性差异(P>0.05)。结论雷贝拉唑、阿莫西林和硫糖铝三联疗法能有效地根除HP,溃疡愈合率高,安全且耐受性好,是一种较理想的HP根除新方案。
参考文献
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