Labrasol对肠P-糖蛋白功能的影响
In vitro modulation of intestinal P-glycoprotein function by labrasol
作者：林玉莲,蒋学华,杨俊毅,周静,张铃敏,山本昌
Author：
收稿日期： 年卷（期）页码：2005,(02):-139-142
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：P-糖蛋白;Labrasol;Ussingchamber;荧光黄;若丹明123
Key words：
基金项目：
中文摘要
目的 研究Labrasol对肠P -糖蛋白功能的影响。方法 用大鼠的离体肠段,通过体外Ussingchamber的转运实验,研究了Labrasol对P -糖蛋白底物若丹明1 2 3转运的影响,同时考察了非P -糖蛋白底物荧光黄在Labrasol作用下的转运行为。结果 低浓度(0 .0 5 %～0 .0 75 %)的Labrasol能够抑制回肠与结肠中P -糖蛋白的功能。同时,对荧光黄的转运无显著影响。结论 Labrasol有望作为P -糖蛋白抑制剂,用于改善受P -糖蛋白介导药物的吸收,提高口服药物的生物利用度。
参考文献
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