4种药物联用在Beagle犬体内的药物动力学
Pharmacokinetics of Tramadol,Venlafaxine hydrochloride,Sulpiride and Rotundine after simultaneous administration in Beagles
作者：李颐;粱茂植;王莉;
Author：
收稿日期： 年卷（期）页码：2006,(02):-143-146
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：药物动力学;盐酸文拉法新;曲马多;颅通定;舒必利;高效液相色谱法
Key words：
基金项目：
中文摘要
目的测定舒必利、曲马多、颅通定和盐酸文拉法新联合给药后,Beagle犬体内的药物动力学的参数变化,揭示4种药物在Beagle犬体内的药物动力学特征。方法24只Beagle犬单次ig不同剂量的舒必利、曲马多、颅通定和盐酸文拉法新的均匀混合粉末,HPLC-Fluor法测定血浆中各成分的浓度,观察剂量增加对4种药物在体内的影响。结果曲马多高剂量组的t1/2较中、低剂量组延长,使Cmax和AUC0-∞显著增高;随着文拉法新剂量的增加,t1/2延长,Cmax和AUC0-∞显著增高;颅通定高剂量组与中、低剂量组比较,Cmax和AUC0-∞的差异均有统计学意义;舒必利亦呈相似的统计学结果。结论Beagle犬体内4种药物的药-时曲线变化均呈一室开放模型,梯度剂量给药后的药-时曲线显示剂量依赖关系,呈一级动力学过程;4种药物间存在药物的相互作用,影响各自在Beagle犬体内的药物动力学过程,尤其显著延长曲马多、万拉法新和舒必利的t1/2。
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