茶树油脂质体的制备及质量评价
Preparation and evaluation of tea tree oil liposome
作者：徐云龙;杨欣欣;徐盛;
Author：
收稿日期： 年卷（期）页码：2006,(02):-139-142
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：茶树油;脂质体;包封率;逆相蒸发法;质量评价
Key words：
基金项目：
中文摘要
目的制备茶树油脂质体并进行质量考察。方法采用逆相蒸发法制备茶树油脂质体,考察单因素制备工艺对包封率的影响和所得产品的形态、粒径、稳定性和体外透皮性。结果卵磷脂胆固醇的质量比为3∶1,药物与脂质原料的质量比为0.0075∶1,PBS与有机溶剂体积比不大于1∶1,超声乳化时间为120 s。制备转速为20 r.min-1时,包封率可达84%;产物形态圆整,粒径为284.7±121.5 nm,冷藏90 d稳定;体外具有明显缓释性。结论逆相蒸发法可以成功地制备茶树油脂质体,包封率高、重复性好、质量稳定,具有优良的缓释性能。
参考文献
[1]Carson CF,Riley TV.Safety,efficacy and provenance of tea tree(Melaleuca alternifolia)oil[J].Contact Dermatitis,2001,45:65-67.
[2]Soderberg TA,Johansson A,Gref R.Toxic effects of some conifer resinacids and tea tree oil on human epithelial and fibroblast cells[J].Tox-icology,1996,107:99-109.
[3]Faoagali J,George N,Leditschke JF.Does tea tree oil have a place inthe topical treatment of burns?[J].Burns,1997,23(4):349-351.
[4]Hausen BM,Reichling J,Harkenthal M.Degradation products of monoterpenes are the sensitizing agents in tea tree oil[J].Contact Dermati-tis,1999,10(2):68-77.
[5]Rubel DM,Freeman S,Southwell LA.Tea tree oil allergy:What is theoffending agent?Report of three cases of tea tree oil allergy and re-view of the literature[J].Dermatology,1998,59:244-247.
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