当归内酯治疗大鼠局灶性脑缺血的作用机制
Therapeutic effects and its mechanism of angelica lactone on focal cerebral ischemia in rats
作者：张光毅;杜俊蓉;旷喜;姚尧;刘研新;汪程远;钱忠明;
Author：
收稿日期： 年卷（期）页码：2006,(02):-114-117
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：当归内酯;脑缺血;红四氮唑;一氧化氮合酶;免疫组化;神经功能评分
Key words：
基金项目：
中文摘要
目的观察当归内酯对局灶性脑缺血大鼠的治疗,并探讨其作用机制。方法线栓法堵塞大脑中动脉起始处,造成大鼠局灶性脑缺血(MCAO),缺血2 h后行神经功能评分。随机将模型大鼠分为当归内酯高、低剂量组和模型组,于再灌04、h时分别灌服受试药物80、20 mg.kg-1或等体积溶媒;假手术组同时灌服等体积溶媒。再灌24 h,各组大鼠再行神经功能评分,经TTC染色法测定脑组织梗死面积,免疫组化方法检测诱导型一氧化氮合酶(iNOS)在脑组织中的表达,分光光度法测定脑组织中iNOS活性及NO含量。结果当归内酯能够显著减小MCAO所致大鼠的脑梗死面积(P
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