利培酮微球在家兔体内外的释药行为
In vivo and in vitro release study of Risperidone microspheres
作者：陈国广;任皓;张桂森;李学明;韦萍;
Author：
收稿日期： 年卷（期）页码：2006,(03):-240-242
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：利培酮;微球;加速实验;缓释
Key words：
基金项目：
中文摘要
目的制备生物可降解的利培酮微球,并考察其在家兔体内外的释放。方法以聚乳酸羟基乙酸为基质,乳化-溶剂挥发法制备利培酮微球,并进行长期及加速体外释放和家兔体内释放研究。结果体外释药可采用溶蚀-扩散模型拟合,微球体内释药平稳,体内外释放相关性好。结论利培酮在体内外具有缓释效果,可采用加速释放实验来模拟体内外释放。
参考文献
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