阿魏酸钠微孔渗透泵控释片的包衣对体外释药的影响
Effects of coating on the in vitro release character of Sodium ferulate controlled porosity osmotic pump tablets
作者:何黎黎;龚涛;李立立;郑玲利;张志荣;
Author:
收稿日期: 年卷(期)页码:2006,(03):-218-221
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:阿魏酸钠;微孔渗透泵片;正交设计;控制释放
Key words:
基金项目:
中文摘要
目的考察包衣处方对阿魏酸钠口服微孔渗透泵控释片体外释药性质的影响,并优选最佳包衣处方。方法根据不同时间的累积释放度,考察药物的释放情况,通过正交设计优化包衣处方。结果增塑剂、包衣膜厚度、致孔剂对阿魏酸钠口服微孔渗透泵控释片体外释药速率的影响均较大,并能通过正交设计得到控制12 h内稳定释药的包衣处方。结论通过对包衣处方的调整,可稳定地控释阿魏酸钠口服微孔渗透泵控释片。
参考文献
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