1,3,5-三-苯甲酰基-2-去氧-2-氟-β-D-核糖的合成
Synthesis of 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofaranose
作者：祝丽华,陈茜,徐云峰,范举正
Author：
收稿日期： 年卷（期）页码：2005,(03):-207-210
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：右旋核糖;氟代;1,3,5-三-苯甲酰基-2-去氧-2-氟-β-D-核糖
Key words：
基金项目：
中文摘要
目的合成1,3,5-三-苯甲酰基-2-去氧-2-氟-β-D-核糖。方法以D-核糖为起始原料,经甲基化、苯甲酰化、溴代脱溴、乙酰化、重排、活化、氟代7步反应,合成目标化合物。结果产物的总收率14.1%,结构经熔点和核磁共振确认。结论所选合成路线减少了反应步骤,改善了反应条件,提高了反应收率。
参考文献
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