参附脱毒胶囊对吗啡依赖大鼠免疫力的影响
Effects of Detoxification capsule on immune furiction of morphine-dependent rats
作者：王雪,郑军然,李静
Author：
收稿日期： 年卷（期）页码：2005,(03):-204-207
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：吗啡;IL-1;IL-6;INF-γ;参附脱毒胶囊
Key words：
基金项目：
中文摘要
目的研究参附脱毒胶囊对吗啡依赖大鼠免疫力的影响。方法30只♂SD大鼠随机均分为生理盐水组、吗啡组、参附组,后两组以剂量递增法建立吗啡依赖大鼠模型,纳洛酮催促戒断后,参附组用参附脱毒胶囊灌胃,盐水组则予等体积生理盐水。采用双抗体夹心酶联免疫吸附法(ELISA)检测各组血清中IL-1、IL-6、INF-γ3个免疫指标的变化。结果与生理盐水组比较,吗啡组和参附组大鼠血清中IL-1的水平显著下降(P0.05),经吗啡和参附处理后,吗啡组与参附组大鼠血清中IL-1、IL-6、INF-γ的水平亦未见明显改变(P>0.05)。结论参附脱毒胶囊对吗啡依赖大鼠的免疫机能无明显影响。
参考文献
[1]MellonRD,BayerBM.Evidenceforcentralopioidreceptersinthe immunomodulatoryeffectsofmorphine:reviewofpotentialmechanismofaction[J].Neuroimmunol,1998,83(1-2):19
[2]YerBM,GasronguayMR,HernandezMC.Distictionbetweenthein vivtroandinvivoinhibitoryeffectsofmorphineonlymphocyteprolif erationbasedonagonistsensitivityandnaltrexonereversibility[J].Immunopharmacology,1992,23:117
[3]McdonoughRJ,maddenJJ,FalekA,etal,AlterationofTandnull lymphocytefrequenciesintheperipheralbloodhumanopiateaddicts:InvivoevidenceforopiatereceptorsitesonTLymphocytes[J].Im munol,1980,125:2539
[4]李静,康林.参附脱毒胶囊与可乐定控制海洛因合戒断症状的随机双盲对照研究[J].中国药物依赖性杂志,2002,11(2):125
[5]ShanhamY,HighfieldD,DefJM,etal.Clonidineblocksstressin ducedreistatementofheroineseekinginRats:aneffectindependent ofthelocuscoeruleusnoraderengicneurous[J].EurNeurosis,2002,12:292
[6]PiazzaPV,LeMoralM.Pathophysiologicalbasisofvulnerabilityto drugabuse:interactionbetweenstress,glucovcoticoids,anddopamin ergicneurons[J].AnnRevPharmacolToxicol,1996,36:359
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