重复性经颅磁刺激对大鼠学习和记忆的影响
Effects of repetitive transcranial magnetic stimulation on learning and memory in rats
作者：李葳;叶青;杨波;王正荣;
Author：
收稿日期： 年卷（期）页码：2006,(04):-325-327
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：重复性经颅磁刺激;Morris水迷宫实验;参考记忆;工作记忆
Key words：
基金项目：国家自然科学基金项目(30470623,30570902);;
美国纽约中华医学会(CMB)基金(Z.Wang)
中文摘要
目的研究重复性经颅磁刺激(repetitive transcran ial m agnetic stimu lation,rTMS)对大鼠学习和记忆的影响。方法W istar♂大鼠接受300次刺激(10 Hz,1.0 Tesla,200μs),用Morris水迷宫实验,考察训练前或后给予大鼠rTMS处理对空间参考记忆和工作记忆的影响。结果训练后施加rTMS可增强空间参考记忆的获取,而训练前施加rTMS则无显著影响;训练前、后施加rTMS对短期和长期参考记忆无显著影响,对工作记忆也无显著影响。结论rTMS对空间参考记忆有增进作用。
参考文献
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