麦冬中几种二氢高异黄酮的立体结构
The stero-structures of homoisoflavonoids from Ophiopogon japonicus
作者：江洪波;田祥琴;胡小兵;黄静;孙奇;陈渝;
Author：
收稿日期： 年卷（期）页码：2006,(05):-416-419
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：麦冬;二氢高异黄酮;圆二色谱;立体构型
Key words：
基金项目：四川大学科技创新基金资助
中文摘要
目的研究麦冬中几种二氢高异黄酮的立体结构。方法采用光谱方法,并用圆二色谱确定立体结构。结果确定6个二氢高异黄酮的立体结构,鉴定结果为:5,7-d ihydroxy-6-m ethyl-8-m ethoxy-3(R)-(2-′hydroxy-4′-m ethoxy-benzyl)chroman-4-one(Ⅰa);5,7-d ihydroxy-6-methyl-8-methoxy-3(S)-(2′-hydroxy-4′-methoxybenzyl)chroman-4-one(Ⅰb);5,7-d ihydroxy-6,8-d im ethyl-3(R)-(3-′m ethoxy-4-′hydroxybenzyl)chrom an-4-one(Ⅱa);5,7-d ihydroxy-6,8-d im ethyl-3(S)-(3′-m ethoxy-4′-hydroxybenzyl)chrom an-4-one(Ⅱb);R-m ethyloph iopogonanone B(Ⅲ)和R-m ethyloph iopogonanone A(Ⅳ)。结论首次确定了6个二氢高异黄酮(Ⅰ~Ⅳ)的立体构型。
参考文献
[1]林晓,周强峰,徐德生.麦冬药理作用研究进展[J].上海中医药杂志,2004,38(06):59-61.
[2]怡悦.麦门冬的细胞毒性成份[J].国外医学.中医中药分册,1999,21(5):42-43.
[3]Kam ei A,Ich ik iH.Antitussive agents and pharmaceutical compo-sitions contain ing methylophiopogonanone[P].CODEN:JKXXAFJP 2003327529 A2,20031113.
[4]Nguyen THA,Tran VS,Andrea P,et a.l Homoisoflavonoids fromoph iopogon japon icus Ker-Gaw ler[J].Phytochem istry,2003,62:1153-1158.
[5]Tada A,Kasa R,Saitoh T,et a.l Stud ies on the constituents ofoph ionogon is tuber V.Isolation of a novel class of homoisofla-vonoids and determ ination of their structure(1)[J].Chem PharmBu ll,1980,28(5):1477.
[6]M ich io N,Tamotsu S.Homoisoflavonoids and related compoundIV absolute configurations of homoisoflavonoids fromCaesalpiniasappanL.[J].Chem Pharm Bu ll,1987,35(9):3597-3602.
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