阿昔洛韦联合羟基脲抗疱疹病毒的研究
Hydroxyurea potentiates the anti-herpes virus activities of acyclovir
作者：杨红,陶佩珍
Author：
收稿日期： 年卷（期）页码：2005,(05):-401-404
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：羟基脲;阿昔洛韦;单纯疱疹性角膜炎;单纯疱疹病毒;抗病毒药物
Key words：
基金项目：
中文摘要
目的研究抗肿瘤药物羟基脲(HU)与抗病毒药物阿昔洛韦(ACV)联用抗疱疹病毒的协同增效作用。方法体外实验应用VERO细胞培养法及MTT染色法进行实验,以Calcusyn软件计算、分析实验结果;体内实验采用单纯疱疹病毒I型感染的兔角膜炎实验模型,用临床裂隙灯观察不同用药情况下兔角膜病变,进行Trouzdale评分,并分离病毒、滴定度及病理检查。结果体外实验结果显示ACV∶HU为1∶312.5及1∶100时,两药为协同作用;ACV∶HU为1∶50、1∶25、1∶10时,两药为拮抗作用。配比为1∶300的阿昔洛韦和羟基脲联合治疗病毒性角膜炎,其疗效与0.1%的ACV相当。结论羟基脲对阿昔洛韦抗HSV-I活性在一定比例条件下,体内、外均有增效作用。
参考文献
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